Want to skip the opening movies and not have to wait for the Cerberus Network every time you start ME2? Easy, just requires two tweaks to your system (instructions for Windows only).
1. Add the -nomoviestartup argument to your ME2 shortcut
c) Change Target from (including quotes: ")
"C:\Program Files (x86)\Mass Effect 2\MassEffect2Launcher.exe"
"C:\Program Files (x86)\Mass Effect 2\Binaries\MassEffect2.exe" -nomoviestartup
and change Start in from
"C:\Program Files (x86)\Mass Effect 2"
"C:\Program Files (x86)\Mass Effect 2\Binaries"
Now when you launch ME2 it should skip the Bioware and EA animated logos and go straight to Press a key on launch.
After this you still have to wait for ME2 to talk to the Internet before you can click the all important Resume. Let's fix that.
2. Block ME2 from accessing the Internet in Windows Firewall
Done! You should now be able to get back into your game as quickly as possible.